welcome to the human experience podcast
the only podcast designed to fuse your
left and right brain hemispheres and
feed it the most entertaining and
mentally engaging topics on the planet
as we approach our scent please make
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strangers thank you for listening the
human experience is traveling like a
vortex up through your spine into your
cerebral cortex as we speak to my guest
dr. Marco iacoboni Marco it’s a pleasure
sir welcome to hxp so Marco I I really
like your bio on your website it reads
quote to be honest I really don’t give a
damn about the brain I care about the
human soul however I believe happen to
believe that the souls in the mind and
the mind is a functional process
instantiated by the brain with its
interactions with the body and the
environment
how interesting oh thank you I must say
that when we rerun the website for the
lab and I asked every one of my trainees
to write a little blurb on themselves
and then we kind of a dry run looking at
the website and they looked at my own
yeah one of my trainees said are you
sure you want to put that thing on on
the website and it is that you know if
you’re a neuroscientist you should
really care about the brain but the
point I was trying to make any kind of a
jokingly fashion is that yeah we study
the brain but why do we celebrate not
because of the brain itself because the
brain is an important organ they really
guides our lives and yet they went you
know to say in a very concise ways that
even though it’s an important organ that
guides our life and determines how we
behave it’s not just the brain the brain
it’s an organ
the body and the body it’s really
embedded and situated in the world and
so we have to consider all these
interactions even when we just study the
brain that was the point of the bird
right so I mean you are most widely
known for your work on mirror neurons
but social cognition and I know that you
like to kind of talk about this how were
mirror neurons discovered what walkest
had a process so other words these
scientists that incidentally wearing in
Italy I’m Italian and I’ve been living
in Los Angeles for almost a quarter of a
century now and never studying system in
the brain of the monkey the controls
grasping grasping is innocent we don’t
even we don’t give it a second thought
but we grasp things all the time if we
are not able to grasp our life is really
severely impaired and so they were
studying other brain controls grasping
because it’s an important way to figure
out how to help patients that have
grasping deficits after say a brain
damaged after like a stroke but one
thing that I found and they were really
surprised and they were so surprised
that initially they wouldn’t believe
themselves that they actually had found
this thing and they did a lot of control
experiments to really make sure that
this was a real phenomenon they found at
some of these cells that really send the
signals from the brain of the monkey to
the muscle of the hand of the monkeys so
that the monkey can grasp like a piece
of rail raising and put him in mouth a
banner and our something like that they
found it some of these cells also file
when the monkey is not moving at all
it’s just who watching someone else
making those grasping actions
so something that if you had asked in
your sand is 25 years ago is there
something in the brain like that they
would had said are you nuts
it’s impossible so there was really nice
shell disbelief but then the idea was
that well when the phenomenon was really
established as a real phenomena the
question was why do we have this stuff
in the brain
what is the adaptive advantage of every
mirror neurons
and so what are the apologies was that
while maybe these cells are really
important for making us understand
what’s going on in the minds of other
people without really having making too
much effort so if I look at you grasping
a cup of coffee and neurons in my brain
that fire up whenever I grasp something
also fire but just watching you grasping
a cup of coffee I had to you know he had
what should do I’m basically activating
in my own brain the same neurons they
activate when we actually are grasping a
cup of coffee and that means that we
have this immediate connection an
immediate understanding of the mental
states and of the actions of other
people hmm very interesting so do do all
mammals have these mirror neurons or is
it just monkeys and humans good question
um these cells were discovered in the
monkey brain now we know we have also
the same cells in the human brain we
know for sure that songbirds those
little cute bears that sing songs learn
how to sing songs through some sort of
mirror neurons his appearance in the
brain of the songbird that fire when the
bird is singing but also when the bird
is listening to the song that he will
eventually sing it is possible to the
arm Union the many other species one of
the idea that we have is that in
principle it could be a fairly simple
mechanism to associate your mother
plants what you plan to do with your
body with the side of someone else doing
the same thing but there is no direct
evidence that there are mirror neurons
in other species at least not so not yet
and because the way near science is done
we tend to study only certain species
with certain techniques so I don’t
really see that we will discover mirror
cells in other animals any time soon but
mostly because people are not really
looking and I would say that if I had to
bet money I would say most likely some
kind of mirroring happens in many
species in many brain
very interesting so how does how does
the evolution and the growth inside the
brain happen when like say for example
when a child is learning looking in a
mirror and realizing that it’s it’s
their own face that they’re seeing how
does that growth happen and what can we
learn from from this yeah that’s a very
good question and I I must say we don’t
have an answer because we don’t have
hard data on this but we have certainly
some speculation that we can make oh you
made a good point that children even
when they’re in the first day of life
can look into it the mirror ring at
their own face or reflected by a mirror
it turns out that they are not even
aware that’s their own face you can make
some test to demonstrate that but they
like to do that I think the mirror
neurons really get created so to speak
by the interactions between the baby and
the caregiver so what happened is that
suppose I’m the baby and you’re the
caregiver humans who tend to do is
adults they tend to actually imitate
what the baby does so if I’m the baby in
and I’m smiling the caregiver tends to
smile back at the baby we like that we
kind of like to join in and what happens
in the baby’s brain the baby’s brain can
simply associate it’s called associative
learning it’s a fairly simple way in
which brains learn out to do things on
the brain of the baby can associate the
motor plan for sale in making a smiling
face in the sight of someone else making
a smiley face and by doing that you
create a mirror room for smile that’s
the way I think actually chameleons are
are actually created we know that
they’re probably I mean we know we
speculate that they’re our premiere
neurons at birth in just in an infant
brain and that’s because even if you
just look at infants really young
infants these the work at any male
surface than some years ago you can show
that infants that were just born few
minutes ago they can imitate some
rudimentary facial gestures like you
know sticking your tongue out or
protruding your lips and
suggested maybe there are some mirroring
cells already at birth but we think that
a lot of mirroring cells in the brain of
the baby actually get developed and are
in a way become stronger and more
represented in the baby
baby’s brain by just these interactions
with the caregiver you talk about in
your research you talk about social
interactions and how people might use
these neurons to establish a higher
social status and I mean what is your
research zone shown about like the the
biomarker of social cognition and how
does this work in regards to how we
relate with other people good question
and we think that xx a mirroring does is
to create this immediate connection it’s
a sort of we call it pre reflective
because again you don’t have to think
about it and these connections really
the basis of one called empathy which is
a fundamental aspect of social behavior
you need to empathize with other people
in order to create a society on the
other hand it’s also true that empathy
is strongly linked to another thing that
we think mirror neurons do which is
imitation through imitation we learn how
to do things if we are in social fairly
noble context we look at other people
behave and we tend to we tend to blend
into the what they do it turns out that
imitation is a fundamental aspects of
human behavior and indeed it’s important
for learning but also it’s important for
transmission of culture it also shows
that imitative behavior in humans that
humans tend to imitate people of two
kinds either people that are like them
or people that have a social status that
they have power influence they were
respected
so what it tells us is that there is
really strong link between the tendency
to empathize and the tendency to
actually conform in a tendency to also
understand our
hierarchies work that tells us that this
mirroring phenomenon is really embedded
as a corner store of our ability to be
social animals to really have mental
states and thoughts and feelings about
other people hmm yeah I mean one of your
one of another one of your quotes that I
really like is while we interact with
other people we find ourselves so it’s
how does this process happening in the
brain itself
I mean how have you guys tested this
well that’s that’s a good question so if
you look for instance in again we can go
back to early in life I told you that
babies in the first year of life that
alighted to play in front of a mirror
and exceed their own image and they
smile and they do things they have no
clue that that’s their own face how do
we know that if the baby falls asleep I
can put a big red mark on his forehead
and when the baby wakes up and he’s in
front of the mirror he still plays but
doesn’t show any change in behavior now
if you do the same trick a year later
when the baby is almost two years old
they’re almost like a toddler Blaine
what happens is that the Trotter wakes
up and looks at the mirror and sees the
big thing on his forehead and then he
starts crushing his forehead so his
behavior or her behavior really shows
that the baby is actually aware that
that face is our own or its own face
okay so that’s called self-awareness now
look let’s look at another phenomenon so
we get a bunch of kids up toward the
secretary of life some of these have
self-awareness they passed the mirror
test they show that this you know
behavior that they’re really worried
about what’s going on on the forehead
with that big red mark some mothers
don’t so they show that they are not
aware that the face at the scene in
front of a mirror is their own face we
put them in pairs a pair kids that are
self-aware and a pair of kids that are
not self-aware what happens to their
imitated behavior what do they do
spontaneously we don’t have to really
tell them what to do they just pull
interacting the kids that have
self-awareness there will be the ones
that imitate Theodore mo the kids
attempt
less self-awareness they didn’t show
much less imitation what does it tell us
it tells us that whenever you acquire
self-awareness you’ll see choir
awareness of the other this is something
for the Western mind is very difficult
to grasp because we are so entrenched
into individualism but for instance in
the Eastern philosophies is well
understood the development of self is
also the development of the other and I
think mirroring really mirroring in the
brain really captures this very well wow
that’s so profound yeah that’s very
interesting how fast do you think this
does the growth of this research is
occurring and how much new information
are we discovering APRA about the brain
oh well it’s going fast I mean we had
really beautiful 10 years ran in which
we did a lovely series of great
experiments which were addressed in
really the big question and so we are
they important for imitation yes at the
important for empathy yes do the Yelp us
understand what’s going on there in the
minds of other people when they plan to
do something yes can they teach us
something about the father for instance
we tend to be more empathic for people
that belong to our own social group so I
tend to empathize more you know I may
give you a cartoonish example more with
another nurse and instead with say a
golf player and that’s also a phenomena
that’s twelve established in the human
behavior and it seems the mirroring is
also relevant to that so we’re done of
these and now we’re trying to address
much more difficult question so for
instance how come people tend to be more
empathic than others or for instance
what is the role of mirroring in mental
health or in mental disorders do we
actually use mirroring for a recover
from say brain damage and if we have say
a motor deficit can we use mirroring to
improve that those are more difficult
questions and so it’s taking us a little
longer to figure out exactly the answers
one thing that we know about
neuroscience know is that there’s plenty
of very good research and especially
plenty of new tools that are coming
along the to help us figure out these
questions what what are some of the
roles that mirror neurons play in
regards to substance abusers and people
who relapse an addiction
good question still we had some
behavioral data it suggested actually
let me give you background information
so we say you get patients that have
alcohol abuse and you put them through a
rehab program first of all not a lot of
patients actually succeed in coming out
of their here program program completely
clean from the substance abuse but
something the problem is that these
problems are very expensive and if you
look at the ones that are successfully
out of there’s just our collab use after
say a rehab program
a year later about two thirds two out of
three of these guys actually are back
into drinking that’s not a good stats
especially because these rehab programs
are fairly expensive and we think that
one of the reason this relapse is
because of Miller meaning if I call it
you know jokingly decide the dark side
of mirroring if I quote with you
supposing you’re outside this drinking
problem and then I’m clean and went
through rehab I’m fine and I’m going out
with you socially seeing you drinking
even though you know you’re not really
getting wasted you just have been glass
of wine because you’re having you know
light out and talking to me about your
life see you’re drinking becomes a
powerful cue for me to go back to
drinking so we have to date one thing we
are trying to do is to figure out can we
actually suppress a little bit mirroring
in these people and that’s the other
complication that we are facing and
trying to figure out how we can do
control of mirroring it’s a very I mean
we’re actually working on my lab is
mostly focusing on that how do you
control mirroring because you if you
figure out how to control it you can
increase it or you can decrease it there
will be an important
thing to do and so we think that in
substance abuse certainly mirroring as
this negative effect of creating this
tendency to relapse in people because
they get these social cues hmm yeah I
find this all very intriguing I mean so
another aspect of your research uses
transcranial magnetic stimulation and in
treating a variety of conditions how
does this treatment work and what makes
it so useful it’s nice about trance can
make a stimulation in other kinds of
techniques that we call journaling
neuromodulation non-invasive
neuromodulation but TMS no stimulation
is probably the best is that they have
non-invasive they’re very little side
effects and they produce for cow
stimulation of brain regions so I can
stimulate to one region of your brain
and the effects of the my stimulation on
to the region also spread throughout
specific circuitry in your brain so we
can target circuits in the brain of
people and we can do that in a way that
really doesn’t induce any side effect
it’s really nice because of these
properties it’s already used fairly
successfully in the treatment of
depression but we think that in
principle can be used for a number of
other conditions and certainly it’s also
well used to study the brain because for
instance the eye thing we do is plane
imaging but with brain imaging whenever
I ask you to do something in DMR scanner
and a sibling region the lights up I’m
never sure that the regions the lights
up is actually causally related to your
behavior but if I use TMS with TMS I can
actually stimulate the brain region and
if I induce a disruption in your
behavior I know that there is a causal
relation between that brain region in
your behavior so these techniques are
really very flexible they give us a lot
of ways of studying the brain and they
also give us the possibility of treating
a number of neurological insecure
disorders without having the side
effects of for McCollum
she has there has there been anything
for you that you’ve found in your within
your research that has been kind of a
Eureka moment or something mind-blowing
that that you can share with our
audience
my research well it’s been a plenty of
really exciting moments for instance
when we started doing the work of
mirroring we know which brain regions
were in the monkey brain that contained
mirror neurons and when I did my first
imaging study on imitation and I found
that very senior regions were showing
the pattern of activity that I thought
would be the pattern of activity that
the mirror neuron area would have that
was some sort of a Eureka moment another
one when we actually applied this kind
of research to patients with all these
memory palaces was that well if these
patients have difficulty in really
relating socially with other people
perhaps it’s because they’re mirroring
capacity is reduced and so if what
mirroring does is really to create this
very easy effortless connection between
people if you don’t have that you can
still interact with others but it
becomes much more requires much more
effort to really have an interaction
with others and to find out in fact
those regions in these patients we
notice that reduce mirroring there was
to me neither in Eureka moment so there
have been a few you’d see one thing I
would say that when I started doing this
work initially I read the scientific
report and then I collaborated with the
with the scientists that they made the
discovery in the monkey brain I must say
that the papers were really you know too
exciting but then I visit the lab and I
saw the monkeys and lay recordings and
you know the activity in these neurons
and there was another Eureka moment it
was just wow you can actually see the
phenomenon as it unfolds in front of you
so these are a number of them it’s been
quite a lot of fun to be involved in
this research yeah you you touched a lot
on empathy as well would you say that
people such as
sociopaths or people such as that of
psychiatric disorders
is this a problem for them I mean you
having empathy because of the decreased
mirror mirror neuron function yeah we
certainly think there is a deficit in
social cognition in a lot of mental
health disorders indeed even in
disorders in which drugs can control the
symptoms let’s take the example of
schizophrenia you may have a patient
with schizophrenia that is an auditory
hallucination the patient hears voices
inside his brain you can control that
with pizza okay with drugs yet when the
patient goes because back in the
community the functioning of these
patients in the community is really not
good and it is that it’s because they
have an impairment in social cognition a
mirror neurons the mirroring and empathy
are really cornerstone of social
cognition so we think that there is a it
widespread interesting mirroring abducts
the mirror Raymond sometimes in there
may be even excessive mirroring in a
number of mental health disorders
certainly empathy you again it’s by many
people many scholars and scientists it’s
considered a cornerstone of social
creation it doesn’t explain all social
cognition but it certainly you need to
add empathy to be a fairly functioning
social agent and lack of empathy or
reduced empathy makes interactions much
more difficult hmm so I mean what is
something that is are there any
exercises that we can do like mental
exercises that help us better imitate or
better fit in socially I would say yes I
mean the first thing you want to do is
to really just be sorta tuned to other
people to really pay attention to what
they do some of these really will come
naturally to people that are naturally
empathic I mean if you are empathic
person you tend to do this naturally but
if you’re not you can relief I wouldn’t
say force yourself you can make some
little exercises which whenever you’re
interacting with someone you really try
to be attuned to them you can even try
to if doesn’t come
pollutants are most people do it
naturally I mean if I we imitate our
postures we imitate our hand gestures
and that we eat ate even the words we
use if I use the word sofa in a
conversation with you you’re gonna
probably use that word sofa in a later
on if rather than using the word couch
so you have a choice but you cannot
imitate me to do you mean you’re in
conversation we tend to do that
naturally but some people may have more
difficulty in doing that it turns out
and if you try to without being you know
too overtly a parrot because if you do
that too then the other person would
became could get a little you know
freaked out about what you’re doing but
if you try to be a tune in a natural way
I just try to follow that the body
language of the other person I think
that that’s a nice way and really simple
way to try to improve your capacity to
empathize to be really attuned to others
yeah I like that you’re your lab is also
looking at the application of mirror
neuron LED teaching ideas in the field
of concept formation and imagination and
role playing in learning and the effect
it has on on sensor motor activity what
has been the results so far and and how
can imagine if role immersion to be
something that we would use to to learn
as a learning tool yeah that’s actually
torture it’s not research is really
doing taking off a lot because I mean
the research we do requires a lot of
funding and we’re not being successful
in recruiting a lot of funding for these
switchers but I think that’s essential I
think you won’t ever do is that we’re
doing it all wrong when it comes to
teaching and learning really learning in
real life it’s a multi-modal experience
what do I mean with that I mean we mean
that I use my my vision I used my
hearing I use my sense of smell I use
the sense of the body that’s the way we
learn not to do things and it turns out
when we when it comes to your the
classroom we tend to have a much more
impoverished way of teaching there are
students sitting around and there is the
teacher in front of them and the teacher
just talks we think that it’s much
better to understand a concept if you
actually use your imagination and you
almost embody the concept you’re trying
to learn and for instance in in Cara
wave almost provocative slogan we say if
you really want to understand the
process of photosynthesis I mean
eventually you’re gonna have to really
learn the details of that that’s being
figured out by the scientists but one
way of doing that is whenever you’re
actually studying the whole process of
photosynthesis you may use your
imagination in imagining you’re the
plant themselves and by doing that your
concepts are actually much more grounded
into something that you understand in a
very solid way we’ve done some studies
on college undergrads here at UCLA and
really wish we were sure that some
subjects actually learn much faster with
this way terms are the summoner’s
actually don’t learn that fast and
that’s the big obstacle we had to kind
of face to figure out which are the
individual differences that make some
people really try with this approach
about teaching and learning and some
others don’t we think it’s a matter of
belief that is if I’m teaching my
undergrads amount I’m telling them I
want you to use your body to mimic the
constant you’re studying some of these
kids will not feel wait a minute are you
treating me like a kindergartener I mean
I’m a smart kid I mean UCLA so why
should I do that
and that creates really drop of empathy
really even empathy for the constant
you’re trying to learn and that’s an
obstacle and that’s not going to help
you hmm it’s very interesting would you
would you say that by by consciously
mirroring like say if I was in a
situation where I needed someone to help
me or to generate empathy from another
person by by consciously mirroring them
would I elicit an empathy
response as long as you do in a very
subtle way yes I mean when it comes to
very young subjects you don’t have to do
it in a very subtle way you can do an
experiment you can go to every rule next
time you’re at the party and there are
very young kids you know maybe in the
first of a second in your life you
imitate what they do and I love it but
if you are interact with a with a with a
cronut what you want to do is to really
try to really be attuned to what they do
and that’s why actually we tend to do
whenever people explain things to us we
know the little it’s not we really have
to not to understand what they’re saying
but by nodding we tell them with our own
body that we’re really under free I mean
listening to what they’re saying and
understanding what they’re saying so
yeah I mean the way you want to do and
by doing that the interesting thing is
that this created a virtuous circle I
mean if you are really attuned to
someone else then the efforts to really
gets drawn to you too and then there is
this really nice bonding between people
it’s one of those things that it’s also
very easy to break down I mean if you
become distracted and you’re looking at
somewhere else oh you’re really thinking
about something that’s that person that
is interacting with you
perceives that immediately and so this
very nice connection can really be
broken very quickly so that’s why I mean
I don’t wanna convey the message that
really is something that you requires a
lot of effort to do this again maybe
because I tend to be a very empathic guy
it comes very natural but I would say
that she’ll really take you long to
really get to attune to others and then
to get people drawn to you too so that
there is this very nice bonding between
people yeah it seems like these cells
play a huge role in in intelligence not
only intelligence but emotional
intelligence and the idea that we can
fit into social groups by you know being
able to imitate what what these people
are doing and and also by looking at the
people that we respect as people who
hold social value and imitating what
they’re doing so it’s very interesting
everything that you guys are doing over
there at
lab what I mean have you have you guys
gotten into any of the theoretical usage
usages of these these mirror neurons yet
what do you read I mean a lot that’s
like like the usage of a program to kind
of simulate like in a computer like
artificial intelligence yeah that’s a
good question actually recently sort of
ex machina which I think it’s the best
movie in artificial intelligence ever
made and yeah I think if you talk to
people that build robots like Miami
college she’s a professor in USC I’ve
talked to her and she told me you know
before you guys discover yourselves
while I was building my robots I was
thinking exactly that I would need
something the mirrors would in my robot
the mirrors what other people are doing
and so yeah there is a lot of both
computational science and robotics and
artificial intelligence that is trying
to capitalize on this phenomenon it
turns out the mirroring it’s probably
even a more widespread phenomenon there
is a recent people just came out this
week that shows that if you look at the
activity in the brain in the motor
cortex and you look at what happens in
the model fibers in your muscles there
is a lot of similarities between the
neurons that fire in your brain and the
activity that your fibers in your
muscles your body parts are doing so
mirroring seems to be really something
that nature exploits a lot and I would
say that if you want to build artificial
entities that are efficient as humans
are and you should probably try to
exploit the mirroring to yeah yeah yeah
yeah that seems like the direction to go
I mean we’re running out of time here
Marco but is there is there anything
that you have discovered recently or
anything that you would like to share
with our audience and this is this would
be the moment to do it oh okay you put
me on the spot the erection
well I mean the thing we’re doing now is
three two and I told you earlier to
figure out how to control it because I
mean you need to assume that if you have
this thing that you know whenever I see
you doing something I tend to do it too
turns out we don’t do that right we
don’t imitate each other all the time
otherwise that would be extremely
dysfunctional and yet we don’t have to
make even an effort to do that so what
we’re trying to do is to figure out what
is the interaction between mirroring
which we call the bottom-up process that
is I see your face smiling and I can’t
help it inside me my mirror self or
smiling no fyra
and most of my top-down processes how do
I control it I mean I’m not it’s not
that whenever you smile as my myself
that’s I think we think that that’s
really that he to figure out how this
interaction creates a very efficient and
fluent social life the other thing I
wanna say is that I’ve been recently
thinking a lot about how this mirroring
phenomenon in its control can actually
go wrong and what do I mean with that I
mean with that that there are situations
in which we tend to rely so much on
either our beliefs or on our practices
that then they interact with the
environment in a sort of bad way and
they can create some really negative
behaviors and I wanna end this by saying
that the more I think about the brain
the biotin it’s really evolution has
divides the brain to make it a device
that really detects action the key that
can be afforded by the environment and
so you wanna have an environment that
really does not afford bad actions and
that really gets into even the level of
policy can you actually use new science
to figure out how to organize society
and I want to say anything more specific
than this because it’s a developing way
of thinking I mean actually maybe the
topic of my next
after reading after writing mirroring
people there was I love that book so
much that for many years I couldn’t
write anything else because I had to
fall in love with another story and I
think I’m slowly falling in love with
this idea that if you look at other
brain works it’s really a device that
detects potential actions and so you
want to create an environment that will
prevent some kinds of actions that will
facilitate some other kinds of actions
let me put it that way I really like
what you said about falling in love with
the idea Marco I really appreciate your
time sir thank you so much for that
where can people find your work if I
think this is very important to create
awareness on this topic where can people
find your work by your book I think mama
JAMA is it you can certainly download it
from online from various Kindle or
iBooks I’m not too happy about you know
publish in the publishing industry in
general but I’ve even you know how the
Amazon if you can find it I don’t think
it’s heavily distributed but it’s been
what school a long seller I mean number
of people keep buying it and I think
it’s it’s a fun book it’s called
mirroring people and I actually try to
ride it in a way that it’s not just
about the science and the concept but
also explains that science even though
we tend to think about it as a kind of
you know this almost impersonal activity
it’s made by people people that have
feelings and emotions and beliefs and so
I try to talk about there too and I
build sort of a narrative from three the
basic science to the implication for our
society a lot of people they read the
books it’s one of the greatest we did
the yet and so of course I have complete
of interest but I still have that book
so much that’s why I have written
another book people keep asking me when
when you write in their book well
whenever I fall in love with in our
story that’s great man do you do you
have a website though yeah I mean why my
website is you actually just Google
iacoboni lab you’ll find it but I’ll
give you the the correct address we can
make that link available in the post
when we post this
what otherwise Marco it’s been great
having you here this is the human
experience thank you guys so much for
listening we will be back next week